Recent Publications:


Stevenson-Paulik, J., Odom, A.R., and York, J.D. Molecular and Biochemical Characterization of Two Plant Inositol Polyphosphate 6-/3-/5-Kinases. (2002) J. Biol. Chem. 277, 42711-42718.

Alb, J.G. Jr., Phillips, S.E., Rostand, K, Cui, X., Pinxteren, J., Cotlin, L., Manning, T., Guo, S., York, J.D., Sontheimer, H., Collawn, J.F. and Bankaitis, V.A. Genetic Ablation of Phosphatidylinositol Transfer Protein Function in Murine Embryonic Stem Cells. (2002) Molecular Biology of the Cell 13, 739-754.

Kontos, C.D., Cha, E.H., York, J.D., and Peters, K.G. The Endothelial Receptor Tyrosine Kinase Tie1 Activates Phosphatidylinositol 3-Kinase and Akt to Inhibit Apoptosis. (2002) Mol. Cell. Biol., 22, 1704-1713.

York, J.D., Guo, S., Odom, A.R., Spiegelberg, B.D., and Stolz, L.E. An Expanded View of Inositol Signaling. (2001) Advan. Enzyme Regul., 41, 57-71.

Tsujishita, Y., Guo, S., Stolz, L.E., York, J.D. and Hurley, J.H. Specificity Determinants in Phosphoinositide Dephosphorylation: Crystal Structure of an Archetypal Inositol Polyphosphate 5-Phosphatase. (2001) Cell, 105, 379-389.

Botelho, R.J., Teruel, M., Dierckman, R., Anderson, R., Wells, A., York, J.D., Meyer, T., and Grinstein, S. Localized Biphasic Changes in Phosphatidylinositol-4,5-Bisphosphate at Sites of Phagocytosis. (2000) J. Cell. Biol., 151,1353-1368.

Ives, E., Nichols, J., Wente, S.R. and York, J.D. Biochemical and Functional Characterization of Inositol 1,3,4,5,6-Pentakisphosphate 2-Kinases. (2000) J. Biol. Chem., 275, 36575-36583.

Aharonovitz O.  Zaun H. C.  Balla TYork J.D.  Orlowski J., and Grinstein S. Intracellular pH regulation by Na+/H+ exchange requires phosphatidylinositol 4,5-bisphosphate. (2000) Journal of Cell Biology. 150, 213-224.

Odom, A.R., Stahlberg, A., Wente, S.R. and York, J.D.  A role for nuclear inositol 1,4,5-trisphosphate kinase in transcriptional control. (2000) Science, 287, 2026-2029.

Raucher, D., Stuaffer, T., Chen, W., Shen, K., Guo, S., York, J.D., Sheetz, M.P., and Meyer, T. Phosphatidylinositol 4,5-bisphosphate functions as a second messenger that regulates cytoskeleton-plasma membrane adhesion. (2000) Cell, 100, 221-228.

Meyer, T. and York J.D. Ca2+ myristoyl switches turn on new lights. (1999) Nature Cell Biology, 1, e93-e95.

York, J.D., Odom, A.R., Murphy, R.,Ives, E.A. and Wente, S.R. A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient mRNA export. (1999) Science, 285, 96-100.

Rivas, M.P., Kearns, B.G., Guo, S., Xie, Z., Sekar, M.C., Hosaka, K. Kagiwada, S., York, J.D. and Bankaitis, V.A. Pleiotropic Alterations in Lipid Metabolism in Yeast sac1 Mutants: Relationship to "Bypass Sec14p" and Inositol Auxotrophy . (1999) Mol. Biol. Cell, 10, 2235-2250.

Guo, S, Stolz, L.E., Lemrow, S.E. and York, J.D. SAC1-like domains of yeast SAC1, INP52 and INP53, and human synaptojanin encode polyphosphoinositide phosphatases. (1999) J. Biol Chem., 274, 12990-12995.

Spiegelberg, B.E., Xiong, J.P., Smith, J.J, Gu,R.F. and York, J.D. Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase, BPntase, inhibited by inositol 1,4-bisphosphate. (1999) J. Biol. Chem, 274, 13619-13628.

Basu, S.S., York, J.D. and Raetz, C.H.R. A phosphotransferase that generates Phosphatidylinositol-4-P from Phosphatidylinositol and Lipid A in Rhizobium leguminosarum. (1999) J. Biol. Chem., 274, 11139-11149.

Kontos, C.D., Stauffer, T.P., Yang, W., York, J.D., Huang, L., Blanar, M.A., Meyer, T. and Peters, K.G.  Tyrosine 1101 of Tie2 is the Major Site of Association of p85 and is Required for Activation of Phosphatidylinositol 3-Kinase and Akt. (1998) Mol. Cell. Biol., 18, 4131-4140.

Stolz, L.E., Kuo, W.J., Longchamps, J., Sekhon, M.K. and York, J.D. INP51A Yeast Inositol Polyphosphate 5-Phosphatase Required for Phosphatidylinositol 4,5 Bisphosphate Homeostasis and Whose Absence Confers a Cold-Resistant Phenotype. (1998), J. Biol. Chem., 273, 11852-11861.

Stolz, L.E., Huynh, C.V. Thorner, J. and York, J.D.  Identification and Characterization of an Essential Family of Inositol Polyphosphate 5-Phosphatases (INP51, INP52 and INP53 Gene Products) in the Yeast Saccharomyces cerevisiae(1998) Genetics, 148, 1715-1729.

York, J.D., Xiong, J.P. and Spiegelberg, B.  Nuclear Inositol Signaling: A Structural and Functional Approach.  (1998) Advances in Enz. Reg., Vol 38.

Poltoratsky, V., Lieber, M., Malik, N., York, J.D. and Carter, T.  DNA-Dependent Protein Kinase is similar to Phosphatidylinositol Lipid Kinases. (1995) J. Immunology 155, 4529-4533.

York, J.D., Ponder, J.W. and Majerus, P.W.  Definition of a Metal-Dependent/Li+-Inhibited Phosphomonoesterase Protein Family Based Upon a Conserved Three-Dimensional Core Structure. (1995) Proc. Natl. Acad. Sci. 92, 5149-5153.

York, J.D., Ponder, J.W., Chen, Z., Mathews, F.S. and Majerus, P.W.  Crystal Structure of Inositol Polyphosphate 1-Phosphatase at 2.3 Å Resolution. (1994) Biochemistry 33, 13164-13171.

York, J.D., Saffitz, J.E. and Majerus, P.W.  Inositol Polyphosphate 1-Phosphatase is Present in the Nucleus and Inhibits DNA Synthesis. (1994) J. Biol.Chem. 269, 19992-19999.

York, J.D., and Majerus, P.W.  Nuclear Phosphatidylinositols Decrease During S-Phase of the Cell Cycle in HeLa Cells. (1994) J. Biol. Chem. 269, 7847-7850.